Johannes M F G Aerts Selected Research

Inflammation (Inflammations)

1/2022	Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
1/2020	Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers.
1/2020	Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities.
8/2017	Activity-based probes for functional interrogation of retaining β-glucuronidases.
4/2012	Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann-Pick C mice.
1/2012	Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
1/2009	Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
10/2005	Marked differences in tissue-specific expression of chitinases in mouse and man.

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Johannes M F G Aerts Research Topics

Disease

57	Gaucher Disease (Gaucher's Disease) 01/2023 - 07/2002
26	Fabry Disease (Fabry's Disease) 12/2021 - 01/2003
8	Inflammation (Inflammations) 01/2022 - 10/2005
8	Insulin Resistance 01/2019 - 02/2007
6	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2024 - 04/2012
6	Type 2 Diabetes Mellitus (MODY) 10/2021 - 01/2009
6	Obesity 04/2021 - 02/2007
4	Parkinson Disease (Parkinson's Disease) 01/2023 - 12/2018
4	Neoplasms (Cancer) 01/2020 - 05/2012
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 02/2024 - 04/2006
3	Glycogen Storage Disease Type II (Pompe's Disease) 08/2023 - 05/2016
3	Niemann-Pick Diseases (Niemann Pick Disease) 01/2023 - 01/2020
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2021 - 01/2020
3	Body Weight (Weight, Body) 10/2014 - 11/2009
3	Pain (Aches) 10/2011 - 10/2002
2	Multiple Sclerosis 04/2021 - 04/2010
2	Globoid Cell Leukodystrophy (Krabbe Disease) 01/2020 - 01/2017
2	Disease Progression 01/2020 - 06/2011
2	Fibrosis (Cirrhosis) 01/2020 - 01/2012
2	Nervous System Diseases (Neurological Disorders) 01/2019 - 01/2017
2	Infections 01/2019 - 06/2009
2	Atherosclerosis 07/2014 - 04/2010
2	Sandhoff Disease (Sandhoff's Disease) 01/2011 - 04/2006
2	Pathologic Processes 01/2009 - 02/2007
2	Renal Insufficiency (Renal Failure) 06/2007 - 08/2003
2	Necrosis 02/2007 - 10/2002
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2024
1	Glycogen Storage Disease (Glycogenosis) 08/2023
1	Tuberculosis (Tuberculoses) 01/2023
1	Neuroinflammatory Diseases 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Cutis Laxa 11/2020
1	Mannosidase Deficiency Diseases (Mannosidosis) 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2020
1	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 01/2020
1	Atopic Dermatitis (Atopic Eczema) 01/2020
1	Netherton Syndrome 01/2020

Drug/Important Bio-Agent (IBA)

24	Glucosylceramidase (Glucocerebrosidase)IBA 02/2024 - 01/2004
22	EnzymesIBA 10/2021 - 07/2002
21	Glucosylceramides (Glucocerebrosides)IBA 01/2023 - 01/2004
14	LipidsIBA 01/2023 - 01/2003
12	GlycosphingolipidsIBA 01/2020 - 02/2007
9	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2004
9	chitotriosidaseIBA 03/2010 - 07/2002
7	GlucosidasesIBA 01/2022 - 01/2011
7	GalactosidasesIBA 12/2021 - 10/2012
7	alpha-Galactosidase (Beano)IBA 01/2017 - 01/2003
7	ceramide glucosyltransferaseIBA 07/2011 - 02/2007
6	Proteins (Proteins, Gene)FDA Link 02/2024 - 01/2003
6	globotriaosylceramide (globotriosylceramide)IBA 12/2021 - 10/2004
6	AcidsIBA 11/2021 - 07/2004
5	sphingosyl beta-glucosideIBA 01/2023 - 04/2015
5	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 03/2007
5	N- (5- adamantane- 1- yl- methoxy- pentyl)deoxynojirimycinIBA 01/2012 - 07/2004
5	AntibodiesIBA 01/2012 - 10/2004
5	Insulin (Novolin)FDA Link 01/2011 - 02/2007
4	CholesterolIBA 02/2024 - 04/2012
4	SphingomyelinsIBA 01/2023 - 01/2020
4	SphingolipidsIBA 01/2021 - 01/2009
4	imiglucerase FDA Link 12/2012 - 02/2007
3	Lysergic Acid Diethylamide (LSD)IBA 01/2023 - 11/2021
3	cyclophellitolIBA 01/2022 - 05/2016
3	globotriaosyl lysosphingolipidIBA 12/2021 - 10/2011
3	CeramidesIBA 01/2021 - 12/2018
3	GlycolipidsIBA 01/2019 - 07/2004
3	ProteomeIBA 01/2017 - 10/2008
3	agalsidase beta FDA Link 02/2011 - 07/2007
2	Glycoproteins (Glycoprotein)IBA 01/2023 - 10/2014
2	IgA receptor (protein B)IBA 01/2023 - 10/2014
2	miglustat (Zavesca)FDA Link 01/2022 - 02/2007
2	Acid CeramidaseIBA 01/2022 - 04/2015
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 11/2021 - 01/2020
2	HydrolasesIBA 01/2017 - 08/2014
2	Mannose (D-Mannose)IBA 01/2017 - 04/2006
2	agalsidase alfaIBA 07/2008 - 07/2007
2	AdiponectinIBA 03/2007 - 02/2007
2	Chemokine CCL18IBA 10/2006 - 01/2004
2	ChitinasesIBA 11/2005 - 10/2005
1	Carrier Proteins (Binding Protein)IBA 02/2024
1	SynucleinsIBA 01/2023
1	human GAA protein (Myozyme)FDA Link 01/2022
1	Starch (Cornstarch)IBA 10/2021
1	Amylases FDA Link 10/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021
1	ApolipoproteinsIBA 01/2021
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 11/2020
1	sphingosine phosphorylcholineIBA 01/2020
1	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA 01/2020
1	Serine Proteases (Serine Protease)IBA 01/2020
1	Polysaccharides (Glycans)IBA 01/2020
1	LDL CholesterolIBA 01/2020
1	Actins (F Actin)IBA 01/2019
1	Mannose ReceptorIBA 01/2019

Therapy/Procedure

17	Therapeutics 08/2023 - 01/2003
17	Enzyme Replacement Therapy 01/2023 - 10/2003
4	Enzyme Therapy 11/2009 - 01/2003